Fenghua Hu

Untargeted Pixel-by-Pixel Imaging of Metabolite Ratio Pairs as a Novel Tool for Biomedical Discovery in Mass Spectrometry Imaging

The paper develops an R package for pixel-by-pixel ratio imaging of metabolite pairs in mass spectrometry imaging, enhancing spatial contrast and revealing new tissue regions and biomarkers.

Loss of TMEM106B exacerbates Tau pathology and neurodegeneration in PS19 mice

This study shows that loss of TMEM106B worsens Tau pathology and neurodegeneration in PS19 mice.

Differential regulation of progranulin derived granulin peptides

The paper identifies differential regulation of specific granulin peptides and their glycosylation patterns in relation to lysosomal protease activity and physiological/pathological conditions.

A multifaceted role of progranulin in regulating amyloid-beta dynamics and responses

This study shows that PGRN deficiency affects amyloid-beta levels and microglial activation in a sex- and age-dependent manner, influencing lysosomal activity and inflammation in Alzheimer's disease.

Progranulin deficiency leads to reduced glucocerebrosidase activity

This study shows that progranulin deficiency reduces glucocerebrosidase activity, linking it to lysosomal dysfunction in neurodegenerative diseases.