Marcus Bustamante Smolka

This study identifies Kcs1-dependent inositol pyrophosphates as regulators of DNA repair via Pho80-Pho85 in budding yeast, independent of homologous recombination.

The paper introduces digital-chromosome-banding to analyze meiotic silencing dynamics and identifies sexual dimorphism in meiotic silencing processes.

This paper introduces ProKAS, a proteomic platform for spatial and quantitative analysis of kinase activity using mass spectrometry, and demonstrates its application in studying DNA damage response kinases.

This study identifies PPM1D as a regulator of replication fork restart, showing it prevents excessive nucleolytic degradation and facilitates RAD51-dependent restart, with ATM hyper-signaling counteracting PPM1D loss.

The paper identifies a novel phosphorylation motif in Tel1 signaling that expands the understanding of its role in DNA repair and telomere control.

The paper introduces a high-resolution method using TMP to map torsional stress in yeast chromatin, revealing its role in transcription and 3D genome organization.

The paper develops a system for mitosis-specific protein recruitment to the plasma membrane using a phosphorylation-controlled switch, without exogenous triggers.

MAGMa is a tool for differential expression analysis in mass-spectrometry proteomic data, showing improved sensitivity and specificity in detecting true signals.

This paper investigates the role of FANCJ in meiotic recombination in mice, finding it involved in early DSB repair and NCO formation but not in MLH1-mediated CO events.

This study identifies how Mec1/ATR kinase controls homologous recombination to suppress gross chromosomal rearrangements through Rad53 and Sgs1 pathways.

The paper identifies Rad53-dependent protein localization changes during replication stress, revealing Mec1-independent activation of Rad53 in yeast.

This study shows that multiple 9-1-1 complexes are essential for meiotic DSB repair, homolog synapsis, and ATR signaling in mammals.

This study identifies ATR-dependent phosphorylation sites in mouse meiosis, revealing key targets and motifs involved in DNA repair and RNA processing during prophase I.

This study identifies a distinct Mec1/ATR signaling mode triggered by DNA end hyper-resection, showing its role in regulating HR-mediated DNA repair through phosphorylation of the STR complex.

This paper develops a quantitative phosphoproteomic approach to improve reliability and reduce false positives in kinase signaling network analysis, expanding the Mec1 and Tel1 networks.

MaXLinker improves cross-link identification by reducing false positives and increasing sensitivity, revealing 9,319 cross-links in K562 cells.

This study shows that progranulin deficiency reduces glucocerebrosidase activity, linking it to lysosomal dysfunction in neurodegenerative diseases.