Author

Mitchell D. Pagan

Cornell University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:differential expression· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Fenghua HuiD· 2 shared Mariela Nunez Santos· 2 shared Daniel H. Paushter· 1 shared Dong-Sung KimiD· 1 shared Herman S. OverkleeftiD· 1 shared Huan DuiD· 1 shared Lianne Jillian TrigianiiD· 1 shared Marcus Bustamante SmolkaiD· 1 shared

Activity by Year

2019-2022 · peak 1/yr

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10 top collaborators · 30 mutual co-author links

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2 shared papersNeuroscience

Fenghua HuORCID

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2 papers

Recent·Most cited

Differential regulation of progranulin derived granulin peptides

Tingting Zhang, Huan Du, Mariela Nunez Santos, Xiaochun Wu, Mitchell D. Pagan, Lianne Jillian Trigiani, Nozomi Nishimura, Thomas Reinheckel, Fenghua Hu

The paper identifies differential regulation of specific granulin peptides and their glycosylation patterns in relation to lysosomal protease activity and physiological/pathological conditions.

Molecular Neurodegeneration · Feb 4, 2022Peer-reviewedNeuroscience

Progranulin deficiency leads to reduced glucocerebrosidase activity

Xiaolai Zhou, Daniel H. Paushter, Mitchell D. Pagan, Dong-Sung Kim, Mariela Nunez Santos, Raquel L. Lieberman, Herman S. Overkleeft, Ying Sun, Marcus Bustamante Smolka, Fenghua Hu

This study shows that progranulin deficiency reduces glucocerebrosidase activity, linking it to lysosomal dysfunction in neurodegenerative diseases.

PLoS ONE · Jul 10, 2019Peer-reviewedNeuroscience