Histone deacetylase 5 in prelimbic prefrontal cortex limits context-associated cocaine seeking
Sarah M. Barry, Jessica L. Huebschman, Derek M. DeVries, Lauren M McCue, Evgeny Tsvetkov, Rose Marie Akiki, Caroline Limbaker, Ethan M. Anderson, Daniel J. Wood, Benjamin M. Siemsen, Stefano Berto, Michael D. Scofield, Makoto Taniguchi, Rachel D. Penrod, Christopher W. Cowan
This study shows that HDAC5 in the prelimbic prefrontal cortex reduces context-associated cocaine seeking but not sucrose seeking, altering synaptic gene expression and excitatory/inhibitory balance.
Biological Psychiatry · Jul 7, 2025Peer-reviewedNeuroscience