Christopher W. Cowan

This study shows that HDAC5 in the prelimbic prefrontal cortex reduces context-associated cocaine seeking but not sucrose seeking, altering synaptic gene expression and excitatory/inhibitory balance.

This study shows that EphB1 in GABAergic neurons is essential for guiding cortical glutamatergic axons during brain development by preventing them from following blood vessels.

This study shows that NPAS4 in the medial prefrontal cortex is required for chronic social defeat stress-induced anhedonia and dendritic spine loss, but not social avoidance or anxiety-like behavior.

This study identifies peripheral auditory nerve impairment in a mouse model of MEF2C haploinsufficiency syndrome, linking AN dysfunction to ASD-related behaviors and immune cell involvement.

This study shows NPAS4 regulates drug-cue associations and relapse-like behavior by controlling the activation balance between D1- and D2-MSNs in the nucleus accumbens.

This study shows that chronic methamphetamine exposure in rats causes cognitive deficits by increasing inhibitory synaptic transmission in the prefrontal cortex, which can be mitigated by reducing parvalbumin-positive interneuron activity.

The paper identifies a specific subset of nucleus accumbens neurons targeted by prelimbic cortical input that mediate cue-induced cocaine relapse but not sucrose seeking.

This study identifies MEF2C as essential for the biological responses to sleep loss, including gene expression changes and synaptic strength recovery.

This study shows that MEF2C hypofunction in neuronal and neuroimmune populations causes MCHS-like behaviors in mice, highlighting its role in brain development and function.