Makoto Taniguchi

This study shows that HDAC5 in the prelimbic prefrontal cortex reduces context-associated cocaine seeking but not sucrose seeking, altering synaptic gene expression and excitatory/inhibitory balance.

This paper identifies nitrergic interneurons as key mediators of cue-induced synaptic plasticity in D1 MSNs required for cocaine seeking, showing that targeting nNOS or mGluR5 blocks relapse.

This study examines RyR2 expression and localization in the vmPFC during drug and sucrose self-administration and reward recall, finding that drug recall alters RyR2P distribution and increases its somatic expression.

This study shows that NPAS4 in the medial prefrontal cortex is required for chronic social defeat stress-induced anhedonia and dendritic spine loss, but not social avoidance or anxiety-like behavior.

This study shows NPAS4 regulates drug-cue associations and relapse-like behavior by controlling the activation balance between D1- and D2-MSNs in the nucleus accumbens.