Multi-omics reveals global signaling rewiring and identifies Activin A-induced dysregulation of FOS/Activator Protein 1 as a novel target in Fibrodysplasia ossificans progressiva
Marius Wits, Nerea Gomez-Suarez, Alexandre Deber, Nicole Farfán, Fjodor T. Bekedam, Bharath K. Sampadi, Sarah A. Rotman, Daniel Rubiera López, Judit Bestilleiro Márquez, Christiaan H. Arendzen, Christian Freund, Peter A. van Veelen, Aida Llucià Valldeperas, Frances S. de Man, Francesc Ventura, , Gonzalo Sánchez‐Duffhues
The paper uses multi-omics analyses to identify signaling dysregulation in FOP, highlighting AP-1 as a novel therapeutic target.
bioRxiv · Jan 21, 2025 · PreprintMolecular Biology