Peter A. van Veelen

A noncanonical function of Dicer fuels self-dsRNA-driven inflammation

This study identifies a noncanonical role for Dicer in regulating self-dsRNA sensing and innate immune responses to self-derived double-stranded RNA.

Selectivity and dynamics of VAP family tether exchange across membrane contact sites

The paper investigates VAP family tether selectivity and dynamics at membrane contact sites, revealing distinct MCS footprints and compensatory mechanisms in cellular homeostasis.

DNA end-resection is stimulated by an interaction between BRCA1 exon 11 and TOPBP1

The paper identifies a DNA damage- and phospho-dependent interaction between BRCA1 exon 11 and TOPBP1, showing its role in end-resection during homologous recombination.

CRISPR activation screen uncovers MARCKSL1 as a gauge for extracellular vesicle secretion.

The paper identifies MARCKSL1 as a regulator of extracellular vesicle secretion pathways through a CRISPR activation screen and functional studies.

Identification of novel cellular intermediates unveils unique enzymes for flagellar glycan biosynthesis in Clostridioides difficile

This study identifies two novel biosynthetic intermediates and characterizes their enzymes in the unique glycan modification pathway of C. difficile flagellin.

O-GlcNAcylation and low glycolysis underpin Th2 polarization by dendritic cells

This study identifies O-GlcNAcylation and reduced glycolysis as key factors in Th2 polarization by dendritic cells, showing their role in immune synapse regulation and TCR signaling.

VAPB and its binding partner AKAP11 promote lipid droplet degradation

This study identifies VAPB and AKAP11 as regulators of lipid droplet homeostasis by mediating neutral lipid degradation through membrane contact sites and PKA activity.

Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose

The paper identifies RNF114 as a specific reader of ubiquitinated ADP-ribose using a chemoproteomics approach and validates its interaction with the modified molecule.

Huib32: A Potent and Selective USP32 Inhibitor Modulating Endosomal Processes and Advancing Cell-Permeable USP32 Probes

This paper introduces Huib32, a selective USP32 inhibitor, and two activity-based probes that modulate endosomal processes and provide tools for studying USP32 in cancer and neurodegenerative diseases.

Elucidation of the glycan structure of the b-type flagellin of Pseudomonas aeruginosa PAO1

This study identifies the unknown moiety in the b-type flagellin glycan of Pseudomonas aeruginosa PAO1 as N,N-dimethylthreonine using mass spectrometry and compares it to Type A glycan in C. difficile.

Multi-omics reveals global signaling rewiring and identifies Activin A-induced dysregulation of FOS/Activator Protein 1 as a novel target in Fibrodysplasia ossificans progressiva

The paper uses multi-omics analyses to identify signaling dysregulation in FOP, highlighting AP-1 as a novel therapeutic target.

Vault RNAs aid viral infection by facilitating nuclear export of hnRNP C and ELAVL1

This study shows that vault RNAs enhance viral replication by facilitating the nuclear export of ELAVL1 and hnRNP C, which are required for efficient viral replication.

Development of covalent probes to capture Legionella pneumophila effector enzymes

The paper develops covalent probes to target Legionella pneumophila effector enzymes, demonstrating their effectiveness in capturing DupA through in vitro testing and structural analysis.

BRCA1/BARD1 ubiquitinates PCNA in unperturbed conditions to promote replication fork stability and continuous DNA synthesis.

The paper identifies PCNA as a substrate of BRCA1/BARD1 ubiquitin E3 activity, showing it promotes replication fork stability and continuous DNA synthesis without requiring Homologous Recomberation or Olaparib resistance.

Non-prime- and Prime-side Profiling of Pro-Pro Endopeptidase Specificity Using Synthetic Combinatorial Peptide Libraries and Mass Spectrometry

The paper characterizes the non-prime- and prime-side specificity of Pro-Pro endopeptidases using synthetic peptide libraries and mass spectrometry, identifying novel PPEPs and altered specificity in mutants.

SUMO Activated Target Traps (SATTs) enable the identification of a comprehensive E3-specific SUMO proteome.

The paper introduces SATTs to identify E3-specific SUMO substrates, finding 1681 SUMO substrates across eight E3s with distinct preferences.