Author

Christian Freund

Leiden University Medical CenterPrimary ORCID profile (0000-0001-7416-8226 · 4 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Christian FreundiD4 papers · Freie Universität Berlin

Biology Disciplines

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Developmental Biology· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Approach:statistical model· 2 Assay:ChIP-seq· 1 Research Focus:clustering· 1

Frequent Co-Authors

Aida Llucià ValldeperasiD· 1 shared Alexandre DeberiD· 1 shared Alyxandra T. Curtis· 1 shared Arend W. OvereemiD· 1 shared Bharath K. SampadiiD· 1 shared Bruno Calabretta· 1 shared Celine M. RoelseiD· 1 shared Chiara ScopaiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperMolecular Biology

Aida Llucià ValldeperasORCID

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3 papers

Recent·Most cited

Multi-omics reveals global signaling rewiring and identifies Activin A-induced dysregulation of FOS/Activator Protein 1 as a novel target in Fibrodysplasia ossificans progressiva

Marius Wits, Nerea Gomez-Suarez, Alexandre Deber, Nicole Farfán, Fjodor T. Bekedam, Bharath K. Sampadi, Sarah A. Rotman, Daniel Rubiera López, Judit Bestilleiro Márquez, Christiaan H. Arendzen, Christian Freund, Peter A. van Veelen, Aida Llucià Valldeperas, Frances S. de Man, Francesc Ventura, , Gonzalo Sánchez‐Duffhues

The paper uses multi-omics analyses to identify signaling dysregulation in FOP, highlighting AP-1 as a novel therapeutic target.

bioRxiv · Jan 21, 2025 · PreprintMolecular Biology

Efficient and scalable generation of primordial germ cells in 2D culture using basement membrane extract overlay

Arend W. Overeem, Yolanda W. Chang, Ioannis Moustakas, Celine M. Roelse, Sanne Hillenius, Talia van der Helm, Valérie F. Van Der Schrier, Manuel A.F.V. Gonçalves, Hailiang Mei, Christian Freund, Susana M. Chuva de Sousa Lopes

This paper introduces a method to efficiently generate human primordial germ cell-like cells (hPGCLCs) in 2D culture using basement membrane extract overlay and low BMP4 concentration.

Cell Reports Methods · Jan 1, 2022Peer-reviewedDevelopmental Biology

Inability to switch from ARID1A-BAF to ARID1B-BAF impairs exit from pluripotency and commitment towards neural crest formation in ARID1B-related neurodevelopmental disorders

Luca Pagliaroli, Patrizia Porazzi, Alyxandra T. Curtis, Chiara Scopa, Harald M. M. Mikkers, Christian Freund, Lucia Daxinger, Sandra Deliard, Sarah A. Welsh, Sarah R. Offley, Connor A. Ott, Bruno Calabretta, Samantha A. Brugmann, Gijs W.E. Santen, Marco Trizzino

This study shows that failure to switch from ARID1A-BAF to ARID1B-BAF in patient-derived cells impairs neural crest formation in Coffin-Siris syndrome.

Nature Communications · Nov 9, 2021Peer-reviewedGenomics