Author

Sarah A. Rotman

Leiden University Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Peter A. van VeeleniD· 3 shared A van der Meulen - de de JongiD· 1 shared Aida Llucià ValldeperasiD· 1 shared Alexandre DeberiD· 1 shared Andrii GorelikiD· 1 shared Arnoud H. de RuiD· 1 shared Bharath K. SampadiiD· 1 shared Bianca D. M. van ToliD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersMolecular Biology

Peter A. van VeelenORCID

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Author profile →

3 papers

Recent·Most cited

VAPB and its binding partner AKAP11 promote lipid droplet degradation

Shalom Borst Pauwels, Menno Spits, Lennert Janssen, Sarah A. Rotman, Arnoud H. de Ru, A van der Meulen - de de Jong, Erik Bos, Peter A. van Veelen, Roman I. Koning, Martin A. Giera, Jacques Neefjes, Birol Cabukusta

This study identifies VAPB and AKAP11 as regulators of lipid droplet homeostasis by mediating neutral lipid degradation through membrane contact sites and PKA activity.

bioRxiv · Jan 27, 2026 · PreprintCell Biology

Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose

Max S. Kloet, Chatrin Chatrin, Rishov Mukhopadhyay, Bianca D. M. van Tol, Rebecca Smith, Sarah A. Rotman, Rayman T.N. Tjokrodirijo, Kang Zhu, Andrii Gorelik, Lucy Maginn, P.R. Elliott, Peter A. van Veelen, Dragana Ahel, Ivan Ahel, Gerbrand J. van der Heden van Noort

The paper identifies RNF114 as a specific reader of ubiquitinated ADP-ribose using a chemoproteomics approach and validates its interaction with the modified molecule.

Nature Communications · Jul 9, 2025Peer-reviewedMolecular Biology

Multi-omics reveals global signaling rewiring and identifies Activin A-induced dysregulation of FOS/Activator Protein 1 as a novel target in Fibrodysplasia ossificans progressiva

Marius Wits, Nerea Gomez-Suarez, Alexandre Deber, Nicole Farfán, Fjodor T. Bekedam, Bharath K. Sampadi, Sarah A. Rotman, Daniel Rubiera López, Judit Bestilleiro Márquez, Christiaan H. Arendzen, Christian Freund, Peter A. van Veelen, Aida Llucià Valldeperas, Frances S. de Man, Francesc Ventura, , Gonzalo Sánchez‐Duffhues

The paper uses multi-omics analyses to identify signaling dysregulation in FOP, highlighting AP-1 as a novel therapeutic target.

bioRxiv · Jan 21, 2025 · PreprintMolecular Biology