Tubulin polyglutamylation patterns are central to axon guidance via selective regulation of microtubule-severing enzymes
Daniel Ten Martín, Nicolas Jardin, Juliette Vougny, François Giudicelli, Laïla Gasmi, Véronique Henriot, Laura Lebrun, Cécile Haumaître, Matthias Kneussel, Xavier Nicol, Carsten Janke, Maria M. Magiera, Jamïlé Hazan, Coralie Fassier
The paper shows that tubulin polyglutamylation regulates microtubule-severing enzymes in axon guidance, with TTLL6 and TTLL11 having distinct roles in zebrafish and mammalian neurons.
bioRxiv · Jan 20, 2022 · PreprintDevelopmental Biology