Matthias Kneussel

The paper identifies the myelinic channel system as a pathway for microtubule-dependent organelle transport in oligodendrocytes, showing its role in maintaining axonal integrity through neuronal activity and motor proteins.

This study shows that extracellular vesicles from cortical neurons alter spontaneous activity in recipient neurons by increasing postsynaptic potential amplitude.

The paper shows that polyglutamylation of microtubules regulates neuronal remodeling by marking them for severing, affecting synapse and axon pruning in both peripheral and central circuits.

This study identifies an axon-specific microtubule-associated protein signature that drives asymmetric regeneration in sensory neuron axons, using an in vitro model of DRG neurons.

This paper demonstrates that non-enzymatic methods can isolate brain-derived extracellular vesicles without compromising protein integrity, achieving high yield and purity.

This study shows that Tspan15 depletion in mice increases social investigation and aggression, suggesting a role in neuronal circuits controlling aggressive behavior.

The paper identifies TAOK2β as a regulator of translational elongation and shows its disruption leads to increased protein synthesis in an ASD mouse model.

The paper shows that choroid plexus cilia undergo axoneme resorption through microtubule destabilization, controlled by polyglutamylation and spastin, and is conserved in human samples.

This study identifies KIF21B's role in regulating actin dynamics and AMPA receptor removal in dendritic spines during homeostatic synaptic downscaling.

This study shows that katanin, a microtubule-severing complex, is located at dendritic spines and regulates microtubule polymerization and synaptic plasticity through activity-dependent processes.

The paper shows that tubulin polyglutamylation regulates microtubule-severing enzymes in axon guidance, with TTLL6 and TTLL11 having distinct roles in zebrafish and mammalian neurons.

The paper shows that cFos expression in the dentate gyrus changes daily and does not stabilize with spatial memory, yet neurons from early training days still influence later performance.

This study shows SIPA1L2 connects TrkB-containing amphisomes to dynein for retrograde trafficking and local signaling at presynaptic terminals, essential for BDNF-dependent plasticity.

This study identifies myosin V as essential for synaptopodin clustering at post-synaptic sites, showing that the spine apparatus is assembled locally rather than transported.