Molecular characterization of the archaic HLA-B*73:01 allele reveals presentation of a unique peptidome and skewed engagement by KIR2DL2
Philipp Ross, Hugo G. Hilton, Jane E. Lodwick, Tomasz Ślężak, Lisbeth A. Guethlein, Curtis McMurtrey, Alex S. Han, Morten Nielsen, Daniel Yong, Charles L. Dulberger, Kristof T. Nolan, Sobhan Roy, Caitlin D. Castro, William H. Hildebrand, Minglei Zhao, , Erin J. Adams
The paper characterizes HLA-B*73:01, revealing its unique peptide binding motif, restricted peptidome, and distinct interaction with KIR2DL2, suggesting evolutionary advantages in pathogen resistance.
Journal of Biological Chemistry · Jul 30, 2025Peer-reviewedBiochemistry