Author

Tomasz Ślężak

University of ChicagoORCID 0000-0002-2931-0331Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:proteomics· 4 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Anthony A. KossiakoffiD· 4 shared Kelly M. O’LearyiD· 2 shared Ahmed RohaimiD· 1 shared Ainhoa ArinaiD· 1 shared Aleksandra Zieminska· 1 shared Alex S. HaniD· 1 shared Anna AndrzejczakiD· 1 shared Annika M. Sääf· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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4 shared papersBiochemistry

Anthony A. KossiakoffORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Dynamic translocation of Inside-Out proteins to the cell surface underlies cellular adaptation to cancer-induced stress

Tomasz Ślężak, Kelly M. O’Leary, Tanya Guevara Avella, Natalia Musiał, Jinyang Li, Anna Andrzejczak, Elizabeth F. Scott, Duc Anh Le, Anthony A. Kossiakoff

The paper identifies and characterizes Inside-Out (I-O) proteins on cancer cell surfaces, showing their dynamic trafficking and link to stress response mechanisms.

Proceedings of the National Academy of Sciences · Mar 24, 2026Peer-reviewedBiochemistry

Molecular characterization of the archaic HLA-B*73:01 allele reveals presentation of a unique peptidome and skewed engagement by KIR2DL2

Philipp Ross, Hugo G. Hilton, Jane E. Lodwick, Tomasz Ślężak, Lisbeth A. Guethlein, Curtis McMurtrey, Alex S. Han, Morten Nielsen, Daniel Yong, Charles L. Dulberger, Kristof T. Nolan, Sobhan Roy, Caitlin D. Castro, William H. Hildebrand, Minglei Zhao, , Erin J. Adams

The paper characterizes HLA-B*73:01, revealing its unique peptide binding motif, restricted peptidome, and distinct interaction with KIR2DL2, suggesting evolutionary advantages in pathogen resistance.

Journal of Biological Chemistry · Jul 30, 2025Peer-reviewedBiochemistry

A new universal chimeric-antigen receptor (CAR)- fragment antibody binder (FAB) split system for cancer immunotherapy

Ainhoa Arina, Edwin J. Arauz, Karolina Warzecha, Elham Masoumi, Annika M. Sääf, Łukasz Widło, Tomasz Ślężak, Aleksandra Zieminska, Karolina Dudek, Zachary P. Schaefer, Maria Łęcka, Svitlana Usatyuk, Ralph R. Weichselbaum, Anthony A. Kossiakoff

This paper introduces a modular CAR-Fab platform that improves cancer immunotherapy by enabling rapid target redirection and reducing antigen loss variant escape.

Science Advances · Jul 4, 2025Peer-reviewedBioengineering

Engineered Protein-G variants for plug-and-play applications

Tomasz Ślężak, Kelly M. O’Leary, Jinyang Li, Ahmed Rohaim, Elena K. Davydova, Anthony A. Kossiakoff

This paper introduces engineered protein-G variants and Fab scaffolds to create modular, plug-and-play antibody-based assemblies for versatile cell biology applications.

Protein Science · Jan 25, 2025Peer-reviewedBioengineering