Lisbeth A. Guethlein

Molecular characterization of the archaic HLA-B*73:01 allele reveals presentation of a unique peptidome and skewed engagement by KIR2DL2

The paper characterizes HLA-B*73:01, revealing its unique peptide binding motif, restricted peptidome, and distinct interaction with KIR2DL2, suggesting evolutionary advantages in pathogen resistance.

Complex genetic variation in nearly complete human genomes

Hybrid HiFi/ultra-long ONT assemblies of 65 diverse humans yield 130 haplotypes, 1,246 complete centromeres, and a pangenome panel enabling short-read genome inference at median QV 45.

Complete sequences of six Major Histocompatibility Complex haplotypes, including all the major MHC class II structures

The paper completes six MHC haplotypes, including DR1, DR4, and structurally variable C4 regions, improving reference panels for immunogenomics analysis.

Mouse lemur transcriptomic atlas informs primate genes, mutations, physiology, and disease

This paper uses a mouse lemur transcriptomic atlas to identify new genes, splice junctions, and disease-related features, highlighting their relevance to primate biology and human disease.

Adversarial domain translation networks for fast and accurate integration of large-scale atlas-level single-cell datasets

Portal integrates large-scale single-cell datasets efficiently and accurately by preserving biological variation across samples, platforms, and species.

Organism-wide mapping of MHC class I and II expression in mouse lemur cells and tissues

This study maps MHC class I and II expression across all cell types in mouse lemurs using single-cell RNA sequencing data from the Tabula Microcebus atlas, identifying three expression patterns and their association with cell types.