Engineering de novo binder CAR-T cell therapies with generative AI
Markus Mergen, Daniela Abele, Naile Koleci, Alba Schmahl Fernandez, Maya Sugden, Noah Holzleitner, Andreas Carr, Leonie Rieger, Valentina Leone, Maximilian Reichert, Karl‐Ludwig Laugwitz, Florian C. Bassermann, Dirk Hans Busch, Julian Grünewald, Andrea Schmidts
This paper demonstrates the use of generative AI to design de novo binders for CAR-T cells targeting cancer antigens, showing comparable efficacy to traditional scFv-based CAR-T cells.
bioRxiv · Nov 25, 2024 · PreprintBioengineering