Julian Grünewald

The paper identifies HECTD4 as a tumor and metastasis suppressor that targets COX-2 for degradation, with COX-2 stabilization driving pro-tumorigenic effects in breast cancer.

This paper demonstrates the use of generative AI to design de novo binders for CAR-T cells targeting cancer antigens, showing comparable efficacy to traditional scFv-based CAR-T cells.

PrimeDesign is a tool for designing prime editing guide RNAs, enabling single and combination edits, and it supports the creation of a database for over 68,500 pathogenic variants.

The paper describes SECURE-ABE and -CBE base editors with reduced RNA off-target activities and improved DNA editing precision.