Author

Naile Koleci

Technical University of Munich

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Alba Schmahl Fernandez· 1 shared Alexandra Emilia SchlaakiD· 1 shared Andrea SchmidtsiD· 1 shared Andreas CarriD· 1 shared Anna Lena Stippel· 1 shared Bertram BengschiD· 1 shared Charlotte Marie NiemeyeriD· 1 shared Christian FlothoiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBioengineering

Alba Schmahl Fernandez

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2 papers

Recent·Most cited

Oncogenic PTPN11/SHP2 drives immune escape in juvenile myelomonocytic leukemia (JMML) through activation of ectonucleotidase/adenosine signaling

Jovana Rajak, Ke Meng, Anna Lena Stippel, Jun Wang, Naile Koleci, Sheila Bohler, Alexandra Emilia Schlaak, Hui Xiao, Lukas M. Braun, Riccardo Masetti, Robert Zeiser, Christian Flotho, Daniel B. Lipka, Charlotte Marie Niemeyer, Luciana Hannibal, , Miriam Erlacher

This study identifies PTPN11/SHP2-driven adenosine signaling as a mechanism of immune escape in JMML, showing that CD39 inhibition can enhance T cell responses and reduce myeloproliferation.

bioRxiv · Oct 1, 2025 · PreprintCancer Biology

Engineering de novo binder CAR-T cell therapies with generative AI

Markus Mergen, Daniela Abele, Naile Koleci, Alba Schmahl Fernandez, Maya Sugden, Noah Holzleitner, Andreas Carr, Leonie Rieger, Valentina Leone, Maximilian Reichert, Karl‐Ludwig Laugwitz, Florian C. Bassermann, Dirk Hans Busch, Julian Grünewald, Andrea Schmidts

This paper demonstrates the use of generative AI to design de novo binders for CAR-T cells targeting cancer antigens, showing comparable efficacy to traditional scFv-based CAR-T cells.

bioRxiv · Nov 25, 2024 · PreprintBioengineering