Small molecule targeting of FBXO21 mediated p85αubiquitylation in acute myeloid leukemia
Kasidy K. Dobish, Suchita Vishwakarma, Hendrik C. Peters, Carrie Winship, Danielle Alvarado, R. Katherine Hyde, Amarnath Natarajan, Shannon M. Buckley
The paper identifies FBXO21 as a therapeutic target in AML by developing a small molecule that inhibits p85 ubiquitination, reducing PI3K pathway activity and inducing cell death.
bioRxiv · Dec 13, 2024 · PreprintCancer Biology