Cancer BiologybioRxivPreprint
Small molecule targeting of FBXO21 mediated p85αubiquitylation in acute myeloid leukemia
Kasidy K. Dobish, Suchita Vishwakarma, Hendrik C. Peters…·Shannon M. Buckley
The paper identifies FBXO21 as a therapeutic target in AML by developing a small molecule that inhibits p85 ubiquitination, reducing PI3K pathway activity and inducing cell death.
DOI 10.1101/2024.12.13.628427