Retinoic acid breakdown is required for proximodistal positional identity during amphibian limb regeneration
Timothy J. Duerr, Melissa Miller, Sage Kumar, Dareen Bakr, Jackson R. Griffiths, Aditya K. Gautham, Danielle Douglas, S. Randal Voss, James R. Monaghan
This study shows that retinoic acid breakdown via CYP26B1 determines positional identity during amphibian limb regeneration, with Shox playing a key role in PD skeletal element formation.
bioRxiv · Aug 7, 2024 · PreprintDevelopmental Biology