Dareen Bakr

This paper introduces a computational framework to model limb skeletal patterning in mice and axolotls by integrating growth, gene regulation, and signaling spread, showing varying contributions of these factors across limb regions.

This study shows that retinoic acid breakdown via CYP26B1 determines positional identity during amphibian limb regeneration, with Shox playing a key role in PD skeletal element formation.