Timothy J. Duerr

A Characterization of Axolotl Digit Regeneration: Conserved Mechanisms, Divergent Patterning, and a Critical Role for Hedgehog Signaling

TRPV4 Inhibition Reduces Cartilage Growth During Axolotl Limb Regeneration

The paper investigates the role of TRPV4 and PIEZO2 in axolotl limb regeneration, finding that TRPV4 inhibition reduces limb length without affecting cartilage differentiation.

Retinoic acid breakdown is required for proximodistal positional identity during amphibian limb regeneration

This study shows that retinoic acid breakdown via CYP26B1 determines positional identity during amphibian limb regeneration, with Shox playing a key role in PD skeletal element formation.

WISH-BONE: Whole-mount In Situ Histology, to label osteocyte mRNA and protein in 3D adult mouse bones

WISH-BONE labels osteocyte mRNA and protein in 3D adult mouse bones, enabling spatially preserved biomarker expression analysis.

Local mechanical stimuli shape tissue growth in vertebrate joint morphogenesis

The paper investigates how mechanical stimuli influence joint morphogenesis by combining experimental and computational approaches in axolotl limb regeneration.

A constitutively expressed fluorescence ubiquitin cell cycle indicator (FUCCI) in axolotls for studying tissue regeneration

The paper generates a transgenic axolotl line expressing FUCCI to study cell cycle dynamics during tissue regeneration.

3D Visualization of Macromolecule Synthesis

This paper develops a method to visualize and quantify macromolecule synthesis in vivo using click chemistry and light sheet microscopy, demonstrating its sensitivity to biological perturbations.