Neutrophil and NET-driven pulmonary microvascular injury following myocardial injury: attenuation by S100A8/A9 inhibition
Danielle R. Lezama, Orestis Katsoulis, Eloise Marriott, Beata Grygielska, Dean Philip John Kavanagh, Celine Hsi Chen, Millie M Jackson, Ellen Jenkins, Katie Spencer, Emmanuel Abimbola, Nawaal Kiwia, Rahul Y. Mahida, Davor Pavlović, Helen Michelle McGettrick, Babu V Naidu, , Juma El-Awaisi
This study shows that myocardial injury leads to pulmonary microvascular damage driven by neutrophils and S100A8/A9, which can be reduced by inhibiting S100A8/A9.
bioRxiv · Sep 12, 2025 · PreprintImmunology