Structural insights into the ubiquitin independent MIDN-proteasome pathway
Nagesh Peddada, Xue Yun Zhong, Yan Yin, Danielle Renee Lazaro, Jianhui Wang, Stephen Lyon, Jin Huk Choi, Xiao‐chen Bai, Eva Marie Y. Moresco, Bruce Beutler
This study reveals how MIDN enhances proteasome activity through cryo-EM structures showing its binding to proteasomes and substrates in two conformational states.
bioRxiv · Mar 4, 2025 · PreprintBiophysics