Xue Yun Zhong

This study reveals how MIDN enhances proteasome activity through cryo-EM structures showing its binding to proteasomes and substrates in two conformational states.

This study identifies Lrp10 as a negative regulator of CD8 T cell homeostasis and tumor resistance by suppressing IL7R levels and enhancing anti-tumor immunity.

This study evaluates polygenic risk score methods across diverse biobanks and ancestries, finding that European reference panels often yield better performance, while PRS-CS outperforms P+T for high-heritability traits.

This paper shows that meta-analysis fine-mapping is often miscalibrated due to cohort heterogeneity and introduces a QC method to identify suspicious loci.

Candidate Explorer identifies causative mutations for immune phenotypes by integrating multiple data features into a score, improving mutation-phenotype association verification in mice.

This study identifies 5,552 blood-cell trait-variant associations across 746,667 individuals from 5 global populations, including 71 novel loci and ancestry-specific variants not found in European ancestry populations.

The paper integrates genetic, transcriptomic, and clinical data to identify CNV gene associations with brain-related and health traits, finding pleiotropy and multigenicity in CNV biology.

SCINA is a semi-supervised model for analyzing scRNA-Seq and flow cytometry data, improving accuracy and efficiency over unsupervised methods by leveraging gene signatures.