ImmunologybioRxivPreprint
PPa1 insufficiency drives lysosomal storage disease and inflammatory macrophage expansion in the bone marrow.
Magdalena G. Grzemska, Luming Chen, Jamie L. Russell…·Evan Nair‐Gill
DOI 10.64898/2026.03.16.712247
Author
Nagesh Peddada
The University of Texas Southwestern Medical CenterORCID 0000-0003-4033-7305Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2024-2026 · peak 3/yrCo-Author Collaboration Network
10 top collaborators · 24 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship5 papers
Recent·Most cited
- BiochemistrybioRxivPreprint
The Structural Basis of Pacs1-Wdr37 Complex Assembly and Stability
Le Xiao, Magdalena G. Grzemska, Xiong Pi…·Evan Nair‐Gill
This paper presents the cryo-EM structure of the Pacs1-Wdr37 complex, revealing its assembly mechanism and stability, and identifies a mutation linked to neurodevelopmental syndrome.
- BiophysicsJournal of Biomolecular Structure and DynamicsPeer-reviewed
SAXS DATA BASED GLYCOSYLATED MODELS OF HUMAN ALPHA-1-ACID GLYCORPROTEIN, A KEY PLAYER IN HEALTH, DISEASE AND DRUG CIRCULATION
Nidhi Kalidas, Nagesh Peddada, Kalpana Pandey, F. Ashish
The paper uses SAXS data and computational modeling to create glycosylated models of human alpha-1-acid glycoprotein, showing better agreement with experimental data than unglycosylated models.
2 citations - BiophysicsbioRxivPreprint
Structural insights into the ubiquitin independent MIDN-proteasome pathway
Nagesh Peddada, Xue Yun Zhong, Yan Yin…·Bruce Beutler
This study reveals how MIDN enhances proteasome activity through cryo-EM structures showing its binding to proteasomes and substrates in two conformational states.
- BiophysicsInternational Journal of Biological MacromoleculesPeer-reviewed
VISUALIZING THE NUCLEATING AND CAPPED STATES OF F-ACTIN BY Ca2+-GELSOLIN: SAXS DATA BASED STRUCTURES OF BINARY AND TERNARY COMPLEXES
Amin Sagar, Nagesh Peddada, Vikas Choudhary…·F. Ashish
This study uses SAXS to reveal structural insights into how Ca2+-gelsolin depolymerizes and caps F-actin, identifying GA and GA2 complexes as key intermediates.