The hypoxic response extends lifespan through a bioaminergic and peptidergic neural circuit.
Elizabeth S. Kitto, Shijiao Huang, Mira Bhandari, Cassie Tian, Rebecca L. Cox, Safa Beydoun, Emily Qixuan Wang, Danielle Shave, Hillary A. Miller, Sarah A. Easow, Ella Henry, Eugene Chung, Megan L. Schaller, Scott F. Leiser
This study identifies a neural circuit involving HIF-1, serotonin, and other signaling molecules that extends lifespan in C. elegans through hypoxia-induced pathways.
bioRxiv · May 4, 2025 · PreprintPhysiology