Scott F. Leiser

Color-dependent foraging in C. elegans integrates chromoprotein photosensitization with bacterial metabolic cues

This study shows C. elegans uses chromoprotein photosensitization and bacterial metabolic cues to prefer red over blue food, independent of light and photoreceptors.

Food touch limits lifespan through bioamine and neuroendocrine signaling.

This study shows that touch perception interacts with dietary restriction to modulate lifespan in C. elegans through bioamine and neuroendocrine signaling.

The hypoxic response extends lifespan through a bioaminergic and peptidergic neural circuit.

This study identifies a neural circuit involving HIF-1, serotonin, and other signaling molecules that extends lifespan in C. elegans through hypoxia-induced pathways.

fmo-4 promotes longevity and stress resistance via ER to mitochondria calcium regulation in C. elegans

This study shows that fmo-4 in C. elegans extends lifespan and stress resistance by regulating calcium homeostasis through interactions with known longevity pathways.

Fmo5 plays a sex-specific role in goblet cell maturation and mucus barrier formation

This study identifies Fmo5's sex-specific role in goblet cell maturation and mucus barrier formation in the intestine, with severe effects in female mice.

A diet of oxidative stress-adapted bacteria improves stress resistance and lifespan in C. elegans via p38-MAPK.

This study shows that C. elegans fed oxidative stress-adapted bacteria live longer and are more stress-resistant due to activation of the p38-MAPK pathway.

FMO rewires metabolism to promote longevity throughtryptophan and one carbon metabolism

This study identifies FMO-2's role in promoting longevity in C. elegans by rewiring one carbon metabolism and tryptophan metabolism, linking a single enzyme to metabolic pathways involved in lifespan extension.

Serotonin and dopamine modulate aging in response to food perception and availability

The paper identifies compounds that block food perception in C. elegans, increasing longevity by modulating serotonin and dopamine signaling, suggesting a mechanism by which dietary restriction mimetics extend lifespan.

Hypoxic response regulators RHY-1 and EGL-9/PHD promote longevity through a VHL-1 independent transcriptional response.

This study shows that mutations in egl-9 and rhy-1 suppress the long-lived phenotype of vhl-1 mutants in C. elegans, indicating a VHL-1-independent role for EGL-9 and RHY-1 in longevity regulation.