Safa Beydoun

This study shows that touch perception interacts with dietary restriction to modulate lifespan in C. elegans through bioamine and neuroendocrine signaling.

This study identifies a neural circuit involving HIF-1, serotonin, and other signaling molecules that extends lifespan in C. elegans through hypoxia-induced pathways.

This study shows that fmo-4 in C. elegans extends lifespan and stress resistance by regulating calcium homeostasis through interactions with known longevity pathways.

This study identifies Fmo5's sex-specific role in goblet cell maturation and mucus barrier formation in the intestine, with severe effects in female mice.

This study identifies FMO-2's role in promoting longevity in C. elegans by rewiring one carbon metabolism and tryptophan metabolism, linking a single enzyme to metabolic pathways involved in lifespan extension.

The paper identifies compounds that block food perception in C. elegans, increasing longevity by modulating serotonin and dopamine signaling, suggesting a mechanism by which dietary restriction mimetics extend lifespan.