Megan L. Schaller

This study shows that gut SQOR deficiency and high dietary methionine impair colon bioenergetics, alter microbiome, and affect brain function and behavior.

This study identifies a neural circuit involving HIF-1, serotonin, and other signaling molecules that extends lifespan in C. elegans through hypoxia-induced pathways.

This study identifies Fmo5's sex-specific role in goblet cell maturation and mucus barrier formation in the intestine, with severe effects in female mice.

This study shows that C. elegans fed oxidative stress-adapted bacteria live longer and are more stress-resistant due to activation of the p38-MAPK pathway.

This study identifies FMO-2's role in promoting longevity in C. elegans by rewiring one carbon metabolism and tryptophan metabolism, linking a single enzyme to metabolic pathways involved in lifespan extension.

The paper identifies compounds that block food perception in C. elegans, increasing longevity by modulating serotonin and dopamine signaling, suggesting a mechanism by which dietary restriction mimetics extend lifespan.

This study shows that mutations in egl-9 and rhy-1 suppress the long-lived phenotype of vhl-1 mutants in C. elegans, indicating a VHL-1-independent role for EGL-9 and RHY-1 in longevity regulation.