Weight cycling-induced hypothalamic and metabolic tissue immune remodeling is uncoupled from metabolic dysfunctions
Hendrik J.P. van der Zande, Alon Zemer, Frank Vrieling, Lisa Smeehuijzen, Brecht J. Attema, Habib Muallem, Jenny Jansen, Anouk van der Linden, Sivan Prass, Danielle W.R. Wessels, Meirong Ren, Yulia Haim, Evert M. van Schothorst, Sander Kersten, Assaf Rudich, Rinke Stienstra
This study examines the effects of weight cycling on immune remodeling in metabolic tissues and finds that metabolic dysfunctions are uncoupled from inflammation in obese mice.
bioRxiv · Jun 27, 2025 · PreprintImmunology