Hendrik J.P. van der Zande

This study examines how time-restricted feeding affects microglial immunometabolism in obese rats, finding that TRF during the active phase reduces fat mass and alters microglial transcriptome rhythmicity, but does not reverse HFD-induced metabolic inflexibility.

Totum-448 reduces hepatic steatosis and inflammation in diet-induced MASLD mice without affecting body weight or microbiota.

This study examines the effects of weight cycling on immune remodeling in metabolic tissues and finds that metabolic dysfunctions are uncoupled from inflammation in obese mice.