HLA-E-VL9 antibodies enhance NK cell and CD8+ T cell cytotoxicity against HIV-infected CD4+ T cells
Joyce K Hwang, Daniel J. Marston, Marina Tuyishime, Hongbing Yang, Daniel Wrapp, Dapeng Li, Simon Brackenridge, McKenzie Frazier, Brianna Rhodes, Caitlin Harris, Max Quastel, Anyway Brenda Kapingidza, Anna E. Kliszczak, Jacob Gater, Persephone Borrow, , Mihai L. Azoitei
This study develops anti-HLA-E-VL9 antibodies that enhance NK and CD8+ T cell cytotoxicity against HIV-infected cells by blocking NKG2A/CD94 interactions and promoting ADCC.
bioRxiv · Jul 8, 2024 · PreprintImmunology