Daniel J. Marston

Control of Guanine Exchange Factor Activity Using De Novo Designed Protein Inhibitors

This study develops a platform for designing protein inhibitors against Dbl family GEFs, demonstrating their ability to modulate GEF activity in vitro and in cells with high specificity.

RhoG, Rac1 and Cdc42 cooperation in cell protrusion revealed bymultiplexed optogenetics and biosensor imaging

This study uses optogenetics and biosensor imaging to show RhoG activates Rac1 and Cdc42 in cell protrusion, with RhoG's effects on protrusion partially mediated by Rac1 and some independent of it.

A Mammalian Surface Display Platform to Optimize the Antigenicity of Viral Proteins for Vaccine Design

This paper develops a mammalian surface display platform using the PiggyBac transposon system to screen viral protein variants for improved antigenicity in vaccine design.

Iterative immunogen optimization to focus elicited responses on a conserved, subdominant influenza hemagglutinin epitope

The paper designs immunogens that redirect immune responses to a conserved influenza epitope using iterative machine learning and in vivo testing.

HLA-E-VL9 antibodies enhance NK cell and CD8+ T cell cytotoxicity against HIV-infected CD4+ T cells

This study develops anti-HLA-E-VL9 antibodies that enhance NK and CD8+ T cell cytotoxicity against HIV-infected cells by blocking NKG2A/CD94 interactions and promoting ADCC.