Daniel Wrapp

A neutralizing human antibody induces movement of the HCoV-229E receptor binding domain

This study isolates and characterizes neutralizing antibodies against HCoV-229E, showing one antibody induces conformational changes in the viral spike protein.

Iterative immunogen optimization to focus elicited responses on a conserved, subdominant influenza hemagglutinin epitope

The paper designs immunogens that redirect immune responses to a conserved influenza epitope using iterative machine learning and in vivo testing.

Structural Definition of Neutralizing Epitopes within and around the HKU1 Receptor-binding Site Reveals Cell Context-Dependent Neutralization

This study identifies mAbs targeting HCoV-HKU1 spike protein and shows that receptor-binding site recognition alone does not predict neutralization in primary cells.

HLA-E-VL9 antibodies enhance NK cell and CD8+ T cell cytotoxicity against HIV-infected CD4+ T cells

This study develops anti-HLA-E-VL9 antibodies that enhance NK and CD8+ T cell cytotoxicity against HIV-infected cells by blocking NKG2A/CD94 interactions and promoting ADCC.

Continuous flexibility analysis of SARS-CoV-2 Spike prefusion structures

The paper analyzes the conformational dynamics of SARS-CoV-2 Spike prefusion structures using advanced cryo-EM data and reveals a continuous flexibility space rather than discrete states.