The Endoplasmic Reticulum Proteostasis Regulator ATF6 is Essential for Human Cone Photoreceptor Development
Heike Kroeger, Julia M. D. Grandjean, Wei-Chieh Jerry Chiang, Daphne S. Bindels, Rebecca Mastey, Jennifer Okáľová, Amanda Nguyen, Evan T. Powers, Jeffery W. Kelly, Neil Justin Grimsey, Michel Michaelides, Joseph Carroll, R. Luke Wiseman, Jonathan H. Lin
This study shows ATF6 is essential for human cone photoreceptor development and demonstrates that ATF6 activators can restore cone growth in patient-derived retinal organoids.
bioRxiv · Oct 4, 2020 · PreprintDevelopmental Biology