This study investigates the role of atypical p38 signaling in retinal vascular damage using a genetic knock-in mouse model, finding that blocking this pathway reduces vascular damage and pathological angiogenesis.

The FASEB Journal · Dec 13, 2025Peer-reviewedCell Biology

Development of a High-throughput Morphological Assay for Evaluating Mesenchymal Stromal Cell-derived Extracellular Vesicle Modulation of Brain Pericyte Secretory Phenotype

Courtney E. Campagna, Andrew M. Larey, Kanupriya R. Daga, Morgan Roos, Sneha Ghosh, Neil Justin Grimsey, Jin Han, Ross A. Marklein

This study develops a high-throughput morphological assay to evaluate how MSC-EVs modulate brain pericyte secretory phenotype, showing distinct morphological responses under different manufacturing conditions.

Stem Cell Reviews and Reports · Aug 12, 2025Peer-reviewedBioengineering

The Endoplasmic Reticulum Proteostasis Regulator ATF6 is Essential for Human Cone Photoreceptor Development

Heike Kroeger, Julia M. D. Grandjean, Wei-Chieh Jerry Chiang, Daphne S. Bindels, Rebecca Mastey, Jennifer Okáľová, Amanda Nguyen, Evan T. Powers, Jeffery W. Kelly, Neil Justin Grimsey, Michel Michaelides, Joseph Carroll, R. Luke Wiseman, Jonathan H. Lin

This study shows ATF6 is essential for human cone photoreceptor development and demonstrates that ATF6 activators can restore cone growth in patient-derived retinal organoids.

bioRxiv · Oct 4, 2020 · PreprintDevelopmental Biology