Jonathan H. Lin

Coordinated Transcriptional Networks Program Organelle Expansion and Metabolic Flows for High Endothelial Morphology and Function

This study identifies transcriptional networks that coordinate metabolic and secretory pathways in high endothelial cells (HECs) to support immune function and morphology.

Atf6-/- mouse photoreceptors exhibit novel ciliary rootlet defect

This study identifies a novel ciliary rootlet defect in Atf6-/- mouse photoreceptors, linking ATF6 function to cytoskeletal integrity and photoreceptor degeneration.

Ethnic variation and structure-function analysis of tauopathy-associated PERK alleles.

The paper analyzes ethnic variation in PERK alleles linked to tauopathies and shows structural and functional impacts of these variants.

Neurodegeneration Risk Factor, EIF2AK3 (PERK), Influences Tau Protein Aggregation

This study shows that PERK activity prevents tau aggregation and that reduced PERK signaling increases tau neuropathology in tauopathies.

The Endoplasmic Reticulum Proteostasis Regulator ATF6 is Essential for Human Cone Photoreceptor Development

This study shows ATF6 is essential for human cone photoreceptor development and demonstrates that ATF6 activators can restore cone growth in patient-derived retinal organoids.