Author

Julia M. D. Grandjean

Scripps Research InstituteORCID 0000-0002-9247-5841Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

R. Luke WisemaniD· 2 shared Alberto J. M. MartíniD· 1 shared Alexis N. Martinez· 1 shared Amanda NguyeniD· 1 shared Carolina Jerez· 1 shared Claudia A. RiveraiD· 1 shared Claudio A. HetziD· 1 shared Constanza González· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersNeuroscience

R. Luke WisemanORCID

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2 papers

Recent·Most cited

Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the unfolded protein response (UPR) in models of neurodegeneration

René L. Vidal, Denisse Sepúlveda, Paulina Troncoso-Escudero, Paula García-Huerta, Constanza González, Lars Plate, Carolina Jerez, José Cánovas, Claudia A. Rivera, Valentina Castillo, Marisol Cisternas-Olmedo, Sirley Leal, Alexis N. Martinez, Julia M. D. Grandjean, Sonia Donzelli, , Claudio A. Hetz

This study shows that forcing dimerization between ATF6f and XBP1s enhances UPR activity, reducing protein aggregation in neurodegenerative disease models.

Molecular Therapy · Feb 5, 2021Peer-reviewedNeuroscience

The Endoplasmic Reticulum Proteostasis Regulator ATF6 is Essential for Human Cone Photoreceptor Development

Heike Kroeger, Julia M. D. Grandjean, Wei-Chieh Jerry Chiang, Daphne S. Bindels, Rebecca Mastey, Jennifer Okáľová, Amanda Nguyen, Evan T. Powers, Jeffery W. Kelly, Neil Justin Grimsey, Michel Michaelides, Joseph Carroll, R. Luke Wiseman, Jonathan H. Lin

This study shows ATF6 is essential for human cone photoreceptor development and demonstrates that ATF6 activators can restore cone growth in patient-derived retinal organoids.

bioRxiv · Oct 4, 2020 · PreprintDevelopmental Biology