Systematic molecular glue drug discovery with a high-throughput effector protein remodeling platform
Jia Lu, Kate Stuart, Rebecca Teague, Chloe Tarry, Robert Yan, Tabitha Morgan, Elizabeth Nock, Darcie S Mulhearn, Matt Jones, Michael H. Knaggs, Ruben Alvarez Fernandez, Willie Yen, Aris Aristodemou, Eleanor Thompson, Penny Hayward, , Benedict C. S. Cross
This paper introduces a platform for discovering molecular glue degraders by engineering effector proteins to enable systematic identification of new small molecule degraders targeting GSPT1.
bioRxiv · Jul 17, 2025 · PreprintBioengineering