Immunological imprinting shapes the cross-reactive antibody responses to the KP.2 and LP.8.1 vaccine doses
Sanjeev Kumar, Lilin Lai, Madison Ellis, Anamika B. Patel, Devyani Joshi, Jacob W. Vander Velden, Jana Abu Faraj, Sonia Wimalasena, Ramitha R. Pallavi, Jad Iriss, Kareem Bechnak, Peter W. Cook, Meredith Elizabeth Davis Gardner, Heather Hicks, Azaibi Tamin, , Mehul S. Suthar
This study evaluates antibody responses after a KP.2 spike mRNA vaccine dose, showing durable and broadly cross-reactive immunity against multiple SARS-CoV-2 variants, but reduced neutralizing activity against some emerging subvariants.
Journal of Virology · Aug 26, 2026Peer-reviewedImmunology