Author

Daria M Gelfenbein

Russian Academy of Sciences

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Andrey V. KulbachinskiyiD· 2 shared Lidiya LisitskayaiD· 2 shared Alexei A. AraviniD· 1 shared Anastasiya D. OguienkoiD· 1 shared Anton KuzmenkoiD· 1 shared Beatrisa RimskayaiD· 1 shared Egor A. UlashchikiD· 1 shared Ekaterina KropochevaiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersMolecular Biology

Andrey V. KulbachinskiyORCID

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2 papers

Recent·Most cited

Tetramerization and RNA-guided filament assembly control Schlafen-Argonaute antiphage defense

Anton Kuzmenko, Kate Radford, Anastasiya D. Oguienko, Lidiya Lisitskaya, Daria M Gelfenbein, Tsui‐Fen Chou, Andrey V. Kulbachinskiy, Alexei A. Aravin

This study identifies a bacterial antiphage defense system combining Ago and SLFN domains, showing how ATP-driven tetramerization and RNA-guided filament assembly regulate nuclease activity.

bioRxiv · May 30, 2026 · PreprintMolecular Biology

Targeting of human mitochondrial DNA with programmable pAgo nuclease

Beatrisa Rimskaya, Ekaterina Kropocheva, Elza Shchukina, Egor A. Ulashchik, Daria M Gelfenbein, Lidiya Lisitskaya, Vadim V. Shmanai, Svetlana Smirnikhina, Andrey V. Kulbachinskiy, Ilya Mazunin

This study demonstrates that a bacterial Argonaute protein can be targeted to mitochondria to reduce mtDNA copy number in human cells.

Cells · Jan 10, 2026Peer-reviewedMolecular Biology