Author

Egor A. Ulashchik

National Academy of Sciences of BelarusORCID 0000-0002-6617-4375Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Ilya MazuniniD· 2 shared Vadim V. ShmanaiiD· 2 shared Andrey V. KulbachinskiyiD· 1 shared Beatrisa RimskayaiD· 1 shared Daria M Gelfenbein· 1 shared Ekaterina KropochevaiD· 1 shared Elza ShchukinaiD· 1 shared Ivan TarassoviD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersMolecular Biology

Ilya MazuninORCID

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2 papers

Recent·Most cited

Targeting of human mitochondrial DNA with programmable pAgo nuclease

Beatrisa Rimskaya, Ekaterina Kropocheva, Elza Shchukina, Egor A. Ulashchik, Daria M Gelfenbein, Lidiya Lisitskaya, Vadim V. Shmanai, Svetlana Smirnikhina, Andrey V. Kulbachinskiy, Ilya Mazunin

This study demonstrates that a bacterial Argonaute protein can be targeted to mitochondria to reduce mtDNA copy number in human cells.

Cells · Jan 10, 2026Peer-reviewedMolecular Biology

Efficient target cleavage by Type V Cas12a effector programmed with split CRISPR RNA

Regina Tkach, Natalia Nikitchina, Nikita Shebanov, Vladimir M. Mekler, Egor A. Ulashchik, Olga L. Sharko, Vadim V. Shmanai, Ivan Tarassov, Konstantin Severinov, Nina Entelis, Ilya Mazunin

This study shows that AsCas12a can efficiently cleave target DNA using split crRNAs, with residual activity even when only the spacer is present.

bioRxiv · Dec 21, 2020 · PreprintMolecular Biology