Ekaterina Kropocheva

This study demonstrates that a bacterial Argonaute protein can be targeted to mitochondria to reduce mtDNA copy number in human cells.

This study investigates the DNA targeting mechanisms of five bacterial Argonaute proteins in vitro and in vivo, revealing their ability to cleave DNA and defend against bacteriophages.

This paper describes a programmable pAgo nuclease from Kurthia massiliensis that can cleave both DNA and RNA targets with guide flexibility and mismatch sensitivity.