The discovery of 5mC-selective deaminases and their application to ultra-sensitive direct sequencing of methylated sites at base resolution.
Weiwei Yang, Yan‐Jiun Lee, Rebekah M. B. Silva, Amanda N. DeLiberto, Colleen E. Yancey, Daria McCallum, Jackson A. Buss, Rey Moncion, Jennifer L. Ong, Megumu Yamada Mabuchi, David M. Hough, Peter Weigele, Laurence M. Ettwiller
The paper identifies 5mC-selective deaminases and demonstrates their use in ultra-sensitive methylome sequencing at single-base resolution.
Molecular Cell · Apr 16, 2026Peer-reviewedGenomics