Catalytic degradation of circulating targets with FcRn-mediated cycling LYTACs
Christos M. Kougentakis, Matthew J. Shurtleff, Rachel M. Lieser, Tao Chen, C. B. Collins, Isabel E. Johnson, Siyi Gu, Keith T. Akama, Kyle H. Doran, Cyra K. Fung, Darin J. Hildebrandt, Rozhan Khaleghi, Diana Li, Steve Rank, Thomas-Toan Tran, , Nicholas A. Lind
This paper introduces cataLYTACs, a new therapeutic modality that efficiently and durably degrades circulating proteins like IgE in vitro and in vivo, outperforming traditional inhibitors.
bioRxiv · Jan 12, 2025 · PreprintCell Biology