Author

Steve Rank

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Organism:mouse· 1 Organism:non-human primate· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Chris LangsdorfiD· 2 shared Christos M. KougentakisiD· 2 shared Eric D. Turtle· 2 shared Kyle H. Doran· 2 shared Matthew J. ShurtleffiD· 2 shared Ryan W. Holly· 2 shared Tao CheniD· 2 shared Aimei Chen· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersCell Biology

Chris LangsdorfORCID

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Author profile →

2 papers

Recent·Most cited

Catalytic degradation of circulating targets with FcRn-mediated cycling LYTACs

Christos M. Kougentakis, Matthew J. Shurtleff, Rachel M. Lieser, Tao Chen, C. B. Collins, Isabel E. Johnson, Siyi Gu, Keith T. Akama, Kyle H. Doran, Cyra K. Fung, Darin J. Hildebrandt, Rozhan Khaleghi, Diana Li, Steve Rank, Thomas-Toan Tran, , Nicholas A. Lind

This paper introduces cataLYTACs, a new therapeutic modality that efficiently and durably degrades circulating proteins like IgE in vitro and in vivo, outperforming traditional inhibitors.

bioRxiv · Jan 12, 2025 · PreprintCell Biology

Monitoring lysosomal catabolism: a sensitive probe for assessing targeted lysosomal degradation of extracellular proteins

Ryan W. Holly, Yizhen Hu, Vaishnavi Beena Valsan, Christos M. Kougentakis, Nektaria Petronikolou, Tao Chen, Diana Li, Aimei Chen, Steve Rank, Kyle H. Doran, Eric D. Turtle, Chris Langsdorf, Matthew J. Shurtleff

The paper develops a fluorescent probe to monitor lysosomal catabolism of internalized proteins and applies it to assess therapeutic LYTAC agents.

bioRxiv · Oct 18, 2024 · PreprintCell Biology