Author

Chris Langsdorf

Thermo Fisher Scientific (United States)ORCID 0000-0003-2651-052XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Organism:mouse· 1 Organism:non-human primate· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Christos M. KougentakisiD· 2 shared Eric D. Turtle· 2 shared Kyle H. Doran· 2 shared Matthew J. ShurtleffiD· 2 shared Ryan W. Holly· 2 shared Steve Rank· 2 shared Tao CheniD· 2 shared Aimei Chen· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersCell Biology

Christos M. KougentakisORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintJan 12, 2025

Catalytic degradation of circulating targets with FcRn-mediated cycling LYTACs

Christos M. Kougentakis, Matthew J. Shurtleff, Rachel M. Lieser…·Nicholas A. Lind

This paper introduces cataLYTACs, a new therapeutic modality that efficiently and durably degrades circulating proteins like IgE in vitro and in vivo, outperforming traditional inhibitors.

19 citations

humanmouse

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Cell BiologybioRxivPreprintOct 18, 2024

Monitoring lysosomal catabolism: a sensitive probe for assessing targeted lysosomal degradation of extracellular proteins

Ryan W. Holly, Yizhen Hu, Vaishnavi Beena Valsan…·Matthew J. Shurtleff

The paper develops a fluorescent probe to monitor lysosomal catabolism of internalized proteins and applies it to assess therapeutic LYTAC agents.

5 citations

humanproteomics

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