Post-Translational Modifications Control Phase Transitions of Tau
Wyatt C. Powell, McKinley Nahum, Karl Pankratz, Morgane Herlory, James Greenwood, Darya Poliyenko, Patrick Holland, Ruiheng Jing, Luke Biggerstaff, Michael H. B. Stowell, Maciej A. A. Walczak
This study investigates how AD-specific post-translational modifications affect Tau self-assembly into PHFs, finding that phosphorylation generally inhibits aggregation while acetylation has variable effects.
ACS Central Science · Nov 13, 2024Peer-reviewedBiophysics